Adriamycin and daunomycin generate reactive oxygen compounds in erythrocytes
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چکیده
منابع مشابه
Adriamycin and daunomycin generate reactive oxygen compounds in erythrocytes.
Adriamycin and daunomycin produce dose-related cardiac toxicity that may be related to oxygen radicals. Addition of these compounds to human erythrocyte suspensions resulted in stimulation of hexose monophosphate shunt activity that was markedly impaired in the absence of oxyhemoglobin. Evidence for generation of hydrogen peroxide by these compounds was provided by oxidation of reduced glutathi...
متن کاملAdriamycin and Daunomycin Generate Reactive 0 xygen Compounds in Erythrocytes
Adriamycin and daunomycin produce glutathione, by ‘4C-formate oxidation, dose-related cardiac toxicity that may be and by the catalase-aminotriazole trapping related to oxygen radicals. Addition of technique. These experiments indicate these compounds to human erythrocyte that Adriamycin and daunomycin interact suspensions resulted in stimulation of with oxyhemoglobin to generate reactive hexos...
متن کاملComparative Pharmacokinetics of Daunomycin and Adriamycin in Several Animal Species1
The physiological disposition of adriamycin and daunomycin has been studied in several animal species. Both drugs were rapidly cleared from plasma, deposited in tissues, and then excreted slowly. Drug and metabolites were excreted via the bile and urine. Daunomycin was extensively metabolized by mice, rats, dogs, and hamsters, whereas no evidence was obtained for the metabolism of adriamycin in...
متن کاملComparative Biochemical Studies of Adriamycin and Daunomycin in Leukemic Cells1
Adriamycin (AM) and daunomycin (DM) were compared as inhibitors of nucleic acid and protein biosynthesis in LI 210 leukemic cells. In vivo, both antibiotics markedly inhibited, without significant difference, the incorporation of the labeled precursors into DNA and RNA. In vitro, at a concentration of 5 or lOjUg/ml, DM was significantly more effective than AM in inhibiting DNA and RNA synthesis...
متن کاملComparative pharmacokinetics of daunomycin and adriamycin in several animal species.
The physiological disposition of adriamycin and daunomycin has been studied in several animal species. Both drugs were rapidly cleared from plasma, deposited in tissues, and then excreted slowly. Drug and metabolites were excreted via the bile and urine. Daunomycin was extensively metabolized by mice, rats, dogs, and hamsters, whereas no evidence was obtained for the metabolism of adriamycin in...
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ژورنال
عنوان ژورنال: Blood
سال: 1978
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v52.5.878.bloodjournal525878